FEATURES OF THE CONDITION OF ORGANS AND TISSUE OF THE ORAL IN PERSONS WITH METABOLIC SYNDROME IN THE ASPECT OF ORTHOPEDIC DENTAL REHABILITATION USING DENTAL IMPLANTS (LITERATURE REVIEW)
Abstract and keywords
Abstract (English):
At a dental appointment, a large number of patients with general somatic pathology require a purely individual approach to orthopedic rehabilitation. The influence of general somatic changes in metabolic syndrome on the osseointegration of dental implants and the subsequent functioning of orthopedic structures is not in doubt, and is determined by the influence of its components: obesity, arterial hypertension, diabetes mellitus, and dyslipidemia. Objectives. To analyze possible changes in the condition of the organs and tissues of the mouth in people with metabolic syndrome and their impact on the functioning of orthopedic structures supported by dental implants. Methodology. An analysis was carried out of the scientific literature for the period from 2000 to the present, devoted to the influence of somatic pathology, in particular metabolic syndrome, on the condition of the mouth and the functioning of orthopedic structures based on dental implants. Results. Among dental changes in people with metabolic syndrome, in almost all cases there are changes in the organs and tissues of the mouth of varying degrees of severity. The pathogenesis of pathological processes is based on microcirculatory, metabolic, enzymatic and immunological disorders. It is obvious that in patients with metabolic disorders, the risk of development, severity and manifestation of pathological changes in the tissues of the jaws surrounding orthopedic structures supported by dental implants is much higher. Conclusions. An analysis of the literature has fully shown that issues of dental rehabilitation, and especially the use of orthopedic structures based on dental implants as support in people with metabolic syndrome, do not have proper justification and in-depth study. The issues of carrying out important clinical stages in the manufacture of orthopedic structures for people with metabolic syndrome are practically not covered.

Keywords:
dentition defect, dental implantation, dental prosthetics for somatic pathology, prosthetics supported by dental implants, metabolic syndrome, arterial hypertension, diabetes mellitus, obesity
References

1. Avanesyan R.A., Sedova N.N. Medicinskie vozmozhnosti i social'nye riski dental'noy implantologii. Moskva : RUSLAYN. 2015:232. [R.A. Avanesyan, N.N. Sedova. Medical opportunities and social risks of dental implantology. Moscow : RUSLINE. 2015:232. (In Russ.)]. https://elibrary.ru/item.asp?id=24774250

2. Yaremenko A.I., Kotenko M.V., Meysner S.N. i dr. Analiz oslozhneniy dental'noy implantacii. Institut stomatologii. 2015;2(67):46-49. [A.I. Yaremenko, M.V. Kotenko, S.N. Meisner et al. Analysis of complications of dental implantation. Institute of Dentistry. 2015;2(67):46-49. (In Russ.)]. https://elibrary.ru/item.asp?id=23693691

3. Arhipov A.V. Stomatologicheskaya reabilitaciya pacientov s primeneniem dental'nyh implantatov v esteticheski znachimoy zone. Stomatologiya. 2013;1:63-65. [A.V. Arkhipov. Dental rehabilitation of patients with the use of dental implants in an aesthetically significant area. Dentistry. 2013;1:63-65. (In Russ.)]. https://elibrary.ru/item.asp?edn=pxbvaj

4. Bazikyan E.A. Principy prognozirovaniya i profilaktiki oslozhneniy pri dental'noy implantacii (Kliniko-laboratornye issledovaniya) : dis. … dokt. med. Nauk. 14.00.21. Moskva, 2001:250. [E.A. Bazikyan. Principles of prediction and prevention of complications during dental implantation (Clinical and laboratory studies) : dis. ... doc. med. Sciences. 14.00.21. Moscow, 2001:250. (In Russ.)]. https://elibrary.ru/ulmtwf

5. Bogatov E.A. Ortopedicheskoe lechenie pacientov c koncevymi defektami zubnyh ryadov s ispol'zovaniem individual'nyh formirovateley desny s oporoy na dental'nye implantaty. 14.01.14. Moskva, 2020:127. [E.A. Bogatov. Orthopedic treatment of patients with terminal defects of the dentition using individual gum formers supported by dental implants. 14.01.14. Moscow, 2020:127. (In Russ.)]. https://elibrary.ru/item.asp?id=44114351

6. Gayvoronskiy I.V., Smirnova M.A., Gayvoronskaya M.G. Vozmozhnosti komp'yuternoy tomografii v izuchenii osobennostey stroeniya al'veolyarnogo otrostka verhney chelyusti i verhnechelyustnyh pazuh. Vestnik SPbGU. 2009;3:223-228. [I.V. Gaivoronsky, M.A. Smirnova, M.G. Gaivoronskaya. Possibilities of computed tomography in studying the structural features of the alveolar process of the upper jaw and maxillary sinuses. Bulletin of St. Petersburg State University. 2009;3:223-228. (In Russ.)]. https://www.elibrary.ru/item.asp?id=12966647

7. Galikeeva A.Sh. Kliniko-patogeneticheskoe obosnovanie kompleksnogo lecheniya hronicheskogo generalizovannogo parodontita s uchetom narusheniya mineral'nogo obmena i stepeni osteoporoza kostnoy sistemy : dis. … kand. Med. Nauk. Ekaterinburg, 2001:15. [A.Sh. Galikeeva. Clinical and pathogenetic rationale for the complex treatment of chronic generalized periodontitis, taking into account the disturbance of mineral metabolism and the degree of osteoporosis of the skeletal system : dis. ... cand. med. Sciences. Ekaterinburg, 2001:15. (In Russ.)]. https://elibrary.ru/item.asp?id=30642018

8. Garaev Z.I., Dzhavadov R.A., Nasibov H.B. Snizhenie riska razvitiya oslozhneniy dental'noy implantacii. Sovremennaya stomatologiya. 2014;2:74-76. [Z.I. Garayev, R.A. Javadov, Kh.B. Nasibov. Reducing the risk of complications of dental implantation. Modern dentistry. 2014;2:74-76. (In Russ.)]. https://www.elibrary.ru/contents.asp?titleid=28078

9. Gun'ko M.V. Osteoporoz i dental'naya implantaciya. Stomatologiya. 2009;6:73-78. [M.V. Gunko. Osteoporosis and dental implantation. Dentistry. 2009;6:73-78. (In Russ.)]. https://www.elibrary.ru/item.asp?id=13332547

10. Gurevich K.G. i dr. Parodontit. XXI vek. Rukovodstvo dlya vrachey. Moskva. 2016. [K.G. Gurevich et al. Periodontitis. XXI Century. Guide for doctors. Moscow. 2016. (In Russ.)]. https://www.labirint.ru/books/552189/

11. Zelenova E.G., Zaslavskaya M.I., Salina E.V., Rassanov S.P. Mikroflora polosti rta: norma i patologiya. N. Novgorod : NGMA. 2004:158. [E.G. Zelenova, M.I. Zaslavskaya, E.V. Salina, S.P. Rassanov. Microflora of the oral cavity: norm and pathology. N. Novgorod : NGMA. 2004:158. (In Russ.)]. https://elibrary.ru/item.asp?id=19489102

12. Ibragimov T.I. Stomatologicheskaya reabilitaciya bol'nyh pri narusheniyah metabolizma i regionarnogo krovotoka, obuslovlennyh somaticheskimi zabolevaniyami. Rossiyskiy stomatologicheskiy zhurnal. 2002;1:12. [T.I. Ibragimov. Dental rehabilitation of patients with metabolic and regional blood flow disorders caused by somatic diseases. Russian Dental Journal. 2002;1:12. (In Russ.)]. https://www.elibrary.ru/author_items.asp

13. Ivanov S.Yu., Shirokov Yu.E., Goloborod'ko E.I., Duzhinskiy S.V. Osobennosti planirovaniya vnutrikostnoy dental'noy implantacii u pacientov s soputstvuyuschimi serdechno-sosudistymi zabolevaniyami. Institut stomatologii. 2006;3(32):44-45. [S.Yu. Ivanov, Yu.E. Shirokov, E.I. Goloborodko, S.V. Duzhinsky. Features of planning intraosseous dental implantation in patients with concomitant cardiovascular diseases. Institute of Dentistry. 2006;3(32):44-45. (In Russ.)]. https://elibrary.ru/download/elibrary_15274865_88225076.pdf

14. Kalamkarov A.E., Savvidi K.G., Kostin I.O. Osnovnye zakonomernosti vozniknoveniya patologicheskih izmeneniy v kostnoy tkani pri ortopedicheskom lechenii pacientov s ispol'zovaniem dental'nyh vnutrikostnyh implantatov. Institut Stomatologii. 2014;2(63):45-48. [A.E. Kalamkarov, K.G. Savvidi, I.O. Kostin. The main patterns of the occurrence of pathological changes in bone tissue during orthopedic treatment of patients using dental intraosseous implants. Institute of Dentistry. 2014;2(63):45-48. (In Russ.)]. https://elibrary.ru/item.asp?id=22133943

15. Krechina E.K., Zorina O.A., Molchanov A.M., Shilov A.M. Narushenie mikrocirkulyacii v tkanyah parodonta u pacientov s hronicheskim generalizovannym parodontitom v sochetanii s metabolicheskim sindromom. Stomatologiya. 2016;95(1):27-30. [E.K. Krechina, O.A. Zorina, A.M. Molchanov, A.M. Shilov. Impaired microcirculation in periodontal tissues in patients with chronic generalized periodontitis in combination with metabolic syndrome. Dentistry. 2016;95(1):27-30. (In Russ.)]. DOIhttps://doi.org/10.17116/stomat201695127-30.

16. Kulakov A.A., Vinnichenko O.Yu., Badalyan V.A., Korolev V.M. Sravnitel'nyy analiz izmeneniya temperatury kostnoy tkani vo vremya formirovaniya lozha pod dental'nyy implantat tradicion-nym i p'ezohirurgicheskim metodami v dental'noy implantologii. Stomatologiya. 2014;6:30-31. [A.A. Kulakov, O.Yu. Vinnichenko, V.A. Badalyan, V.M. Korolev. Comparative analysis of changes in bone tissue temperature during the formation of a bed for a dental implant using traditional and piezosurgical methods in dental implantology. Dentistry. 2014;6:30-31. (In Russ.)]. https://www.elibrary.ru/contents.asp?id=34048320

17. Kulakov A.A., Gvetadze R.Sh., Braylovskaya T.V. i dr. Sovremennye podhody k primeneniyu metoda dental'noy implantacii pri atrofii i defektah kostnoy tkani chelyustey. Stomatologiya. 2017;96(1):43-45. [A.A. Kulakov, R.Sh. Gvetadze, T.V. Brailovskaya et al. Modern approaches to the use of the dental implantation method for atrophy and defects of the bone tissue of the jaws. Dentistry. 2017;96(1):43-45. (In Russ.)]. DOIhttps://doi.org/10.17116/stomat201796143-45.

18. Kulakov A.A., Kasparov A.S., Hamraev T.K., Porfenchuk D.A. Stabil'nost' implantatov s ranney funkcional'noy nagruzkoy. Klinicheskaya stomatologiya. 2019;2(90):50-54. [A.A. Kulakov, A.S. Kasparov, T.K. Khamraev, D.A. Porfenchuk. Stability of implants with early functional load. Clinical dentistry. 2019;2(90):50-54. (In Russ.)]. DOIhttps://doi.org/10.37988/1811-153X_2019_2_50.

19. Lebedenko I.Yu., Chumachenko E.N., Yanushevich O.O. Primenenie informacionnyh tehnologiy pri planirovanii lecheniya v praktike ortopedicheskoy stomatologii. Rossiyskiy stomatologicheskiy zhurnal. 2010;3:22-26. [I.Yu. Lebedenko, E.N. Chumachenko, O.O. Yanushevich. Application of information technologies in treatment planning in the practice of orthopedic dentistry. Russian Dental Journal. 2010;3:22-26. (In Russ.)]. https://elibrary.ru/item.asp?id=15169969

20. Leonova N.V., Chumakova G.A., Cirikova A.V., Pushkareva S.V. Vliyanie metabolicheskogo sindroma na risk razvitiya oslozhneniy saharnogo diabeta tipa 1. Rossiyskiy kardiologicheskiy zhurnal. 2015;(4):55-58. [N.V. Leonova, G.A. Chumakova, A.V. Tsirikova, S.V. Pushkareva. Influence of metabolic syndrome on the risk of development of complications of type 1 diabetes mellitus. Russian Journal of Cardiology. 2015;(4):55-58. (In Russ.)]. https://doi.org/10.15829/1560-4071-2015-4-55-58

21. Makar'evskiy I.G. Osobennosti ortopedicheskogo lecheniya pri ispol'zovanii dental'nyh implantatov. Klin. implantologiya i stomatologiya. 2002;3-4(21-22):17-25. [I.G. Makarevsky. Features of orthopedic treatment using dental implants. Klin. implantology and dentistry. 2002;3-4(21-22):17-25. (In Russ.)]. https://www.elibrary.ru/author_items.asp?authorid=587306&pubrole=100&show_refs=1&show_option=0

22. Balanova Yu.A., Imaeva A.E., Kucenko V.A. i dr. Metabolicheskiy sindrom i ego associacii s social'no-demograficheskimi i povedencheskimi faktorami riska v rossiyskoy populyacii 25-64 let. Kardiovaskulyarnaya terapiya i profilaktika. 2020:19(4):45-57. [Yu.A. Balanova, A.E. Imaeva, V.A. Kutsenko et al. Metabolic syndrome and its associations with socio-demographic and behavioral risk factors in the Russian population 25-64 years old. Cardiovascular therapy and prevention. 2020;19(4):45-57. (In Russ.)]. DOIhttps://doi.org/10.15829/1728-8800-2020-2600.

23. Nedogoda S.V. Ozhirenie i komorbidnaya patologiya v praktike vracha-terapevta. Izbrannye lekcii po terapii. Moskva, 17-19 noyabrya 2021 goda. Moskva : Obschestvo s ogranichennoy otvetstvennost'yu «KST Grupp». 2021:43-64. [S.V. Nedogoda. Obesity and comorbid pathology in the practice of a general practitioner.Selected lectures on therap. Moscow, November 17-19, 2021. Moscow : Limited Liability Company “KST Group”. 2021:43-64. (In Russ.)]. https://elibrary.ru/item.asp?id=47482287

24. Nikitin Yu.P., Kazeka G.R., Simonova G.I. Rasprostranennost' komponentov metabolicheskogo sindroma X v neorganizovannoy gorodskoy populyacii (epidemiologicheskoe issledovanie). Kardiologiya. 2001;9:37-40. [Yu.P. Nikitin, G.R. Kazeka, G.I. Simonova. Prevalence of metabolic syndrome X in unorganized urban population (epidemiological study). Cardiology. 2001;9:37-40. (In Russ.)]. https://elibrary.ru/item.asp?id=25793040

25. Olesova V.N., Bronshteyn D.A, Stepanov A.F., Kalinina A.N., Lashko I.S. Chastota razvitiya vospalitel'nyh oslozhneniy v periimplantatnyh tkanyah po dannym otdalennogo klinicheskogo analiza. Stomatolog. 2017:58-62. [V.N. Olesova, D.A. Bronshtein, A.F. Stepanov, A.N. Kalinina, I.S. Lashko. Frequency of development of inflammatory complications in peri-implant tissues according to long-term clinical analysis. Dentist. 2017:58-62. (In Russ.)]. https://elibrary.ru/item.asp?id=28362575

26. Paraskevich V.L., Paraskevich V.L. Dental'naya implantologiya : osnovy teorii i praktiki. 3-e izd. Moskva : Med. inform. agentstvo (MIA). 2011:399. [V.L. Paraskevich, V.L. Paraskevich. Dental implantology: fundamentals of theory and practice. 3rd ed. Moscow : Med. information agency (MIA). 2011:399. (In Russ.)]. https://elibrary.ru/item.asp?id=19559959

27. Pashinyan G.A., Bazikyan E.A., Kamalyan A.V. Sovremennye issledovaniya rezul'tatov stomatologicheskoy implantologicheskoy pomoschi putem kompleksnogo analiza vrachebnyh oshibok. Cathedra-Kafedra. Stomatologicheskoe obrazovanie. 2006;5(4):76-80. [G.A. Pashinyan, E.A. Bazikyan, A.V. Kamalyan. Modern studies of the results of dental implantological care through a comprehensive analysis of medical errors. Cathedra-Department. Dental education. 2006;5(4):76-80. (In Russ.)]. https://elibrary.ru/sltoxb

28. Rekomendacii po vedeniyu bol'nyh s metabolicheskim sindromom. Klinicheskie rekomendacii. Moskva. 2013:43. [Recommendations for the management of patients with metabolic syndrome. Clinical recommendations. Moscow. 2013:43. (In Russ.)]. https://scardio.ru/content/Guidelines/projectrecomMS.doc

29. Semenyuk V.M., Stafeev A.A., Struev I.V. Dinamika izmeneniy mineral'noy nasyschennosti u lic s saharnym diabetom pri ortopedicheskoy stomatologicheskoy reabilitacii metallokeramicheskimi konstrukciyami. Maestro stomatologii. 2008;4:72-74. [V.M. Semenyuk, A.A. Stafeev, I.V. Struev. Dynamics of changes in mineral saturation in people with diabetes mellitus with orthopedic dental disease using metal-ceramic structures. Maestro of Dentistry. 2008;4:72-74. (In Russ.)]. https://elibrary.ru/item.asp?id=32708541

30. Stafeev A.A., Hizhuk A.V. Analiz sostoyaniya kostnoy tkani u lic s metabolicheskim sindromom pri planirovanii protezirovaniya nes'emnymi konstrukciyami s oporoy na dental'nye implantaty. Stomatologiya slavyanskih gosudarstv. Sbornik trudov HV Mezhdunarodnoy nauchno-prakticheskoy konferencii, posvyaschennoy 30-letiyu kompanii "VladMiVa", Belgorod, 09-11 noyabrya 2022 goda. Belgorod : Belgorodskiy gosudarstvennyy nacional'nyy issledovatel'skiy universitet. 2022:266-268. [A.A. Stafeev, A.V. Khizhuk. Analysis of the state of bone tissue in persons with metabolic syndrome when planning prosthetics with fixed structures supported by dental implants. Dentistry of the Slavic states. Collection of works of the XV International scientific -practical conference dedicated to the 30th anniversary of the VladMiVa company. Belgorod, November 09-11, 2022. Belgorod : Belgorod State National Research University. 2022:266-268. (In Russ.).]. https://www.elibrary.ru/item.asp?id=53845123

31. Stafeev A.A., Hizhuk A.V. Ocenka sostoyaniya kostnoy tkani u lic s metabolicheskim sindromom. Aktual'nye voprosy stomatologii. Sbornik nauchnyh trudov, posvyaschennyy osnovatelyu kafedry ortopedicheskoy stomatologii KGMU, Professoru Isaak Mihaylovichu Oksmanu, Kazan', 18 fevralya 2023 goda. Kazan' : Kazanskiy gosudarstvennyy medicinskiy universitet. 2023:706-709. [A.A. Stafeev, A.V. Khizhuk. Assessment of the condition of bone tissue in persons with metabolic syndrome. Current issues in dentistry. Collection of scientific papers dedicated to the founder of the Department of Orthopedic Dentistry of KSMU, Professor Isaac Mikhailovich Oksman, Kazan, February 18, 2023. Kazan : Kazan State Medical University. 2023:706-709. (In Russ.)]. https://www.elibrary.ru/item.asp?id=50766516

32. Stafeev A.A. Profilaktika oshibok i oslozhneniy pri stomatologicheskoy ortopedicheskoy reabilitacii bol'nyh s somaticheskoy patologiey nes'emnymi metallokeramicheskimi protezami: special'nost'. 14.00.21 : avtoref. Dis. … doktora medicinskih nauk. Omsk. 2007:46. [A.A. Stafeev. Prevention of errors and complications during dental orthopedic rehabilitation of patients with somatic pathology with fixed metal-ceramic dentures: specialty. 14.00.21 : abstract of the dis. … Doctor of Medical Sciences. Omsk. 2007:46. (In Russ.)]. https://www.elibrary.ru/item.asp?id=15877065

33. Vilkov V.G., Shal'nova S.A., Deev A.D. i dr. Trendy ozhireniya v populyaciyah Rossiyskoy Federacii i Soedinennyh Shtatov Ameriki. Tridcatiletnyaya dinamika. Kardiovaskulyarnaya terapiya i profilaktika. 2018;17(4):67-72. [V.G. Vilkov, S.A. Shalnova, A.D. Deev et al. Trends in obesity in the populations of the Russian Federation and the United States of America. Thirty-year dynamics. Cardiovascular therapy and prevention. 2018;17(4):67-72. (In Russ.)]. DOIhttps://doi.org/10.15829/1728-8800-2018-4-67-72.

34. Ushakov A.I., Serova N.S., Dayan A.V. Planirovanie dental'noy implantacii pri deficite kostnoy tkani i profilaktika operacionnyh riskov. Stomatologiya. 2012;1:48-53. [A.I. Ushakov, N.S. Serova, A.V. Dayan. Planning of dental implantation in case of bone tissue deficiency and prevention of operational risks. 2012;1:48-53. (In Russ.)]. https://elibrary.ru/item.asp?id=18022621

35. Cepov L.M., Cepova E.L. Porazhenie slizistoy obolochki rta i yazyka u lic s patologiey zheludochno-kishechnogo trakta. Vestnik Smolenskoy gosudarstvennoy medicinskoy akademii. 2011;10(1):76-78. [L.M. Tsepov, E.L. Tsepova. Damage to the mucous membrane of the mouth and tongue in persons with pathology of the gastrointestinal tract. Bulletin of the Smolensk State Medical Academy. 2011;10(1):76-78. (In Russ.)]. https://www.elibrary.ru/item.asp?id=17051483

36. Cimbalistov A.V., Robakidze N.S., Karaeva A.Yu. Morfofunkcional'nye izmeneniya gastroduodenal'noy zony u bol'nyh s narusheniem funkcii zhevaniya. Institut stomatologii. 2005;2(27):58-61. [A.V. Tsimbalistov, N.S. Robakidze, A.Yu. Karaeva. Morphofunctional changes in the gastroduodenal zone in patients with impaired chewing function. Institute of Dentistry. 2005;2(27):58-61. (In Russ.)]. https://www.elibrary.ru/item.asp?id=15267411

37. Chazova I.E., Nedogoda S.V., Zhernakova Yu.V. Rekomendacii po vedeniyu bol'nyh s Metabolicheskim sindromom: klinicheskie rekomendacii. Moskva. 2013:43. [I.E. Chazova, S.V. Nedogoda, Yu.V. Zhernakova. Recommendations for the management of patients with Metabolic syndrome: clinical guidelines. Moscow. 2013:43. (In Russ.)]. https://www.elibrary.ru/author_items.asp

38. Sheveleva M.A., Shishkin A.N., Ermolaeva L.A. i dr. Metabolicheskiy sindrom v stomatologicheskoy praktike. Zdorov'e - osnova chelovecheskogo potenciala: problemy i puti ih resheniya. 2018;13(1):400-406. [M.A. Sheveleva, A.N. Shishkin, L.A. Ermolaeva et al. Metabolic syndrome in dental practice. Health is the basis of human potential: problems and ways to solve them. 2018:13(1):400-406. (In Russ.)]. https://www.elibrary.ru/item.asp?id=36773822

39. Alexander C.M., Landsman P.B., Teutsch S.M. NCEF - defined metabolic syndrome, diabetes mellitus, and prevalens of coronary heart disease among NHANES 111 participants age 50 years and older // Diabetes. - 2003;52:1210-1214. DOI:https://doi.org/10.2337/diabetes.52.5.1210

40. Bullon P., Jaramillo R., Santos-Garcia R. et al. Relation of periodontitis and metabolic syndrome with gestational glucose metabolism disorder // J Periodontol. - 2014;85:e1-e8. DOI:https://doi.org/10.1902/jop.2013.130319

41. Feng L., Nyunt M.S. et al. Metabolic Syndrome and the Risk of Mild Cognitive Impairment and Progression to Dementia: Follow-up of the Singapore Longitudinal Ageing Study Cohort // JAMA Neurol. - 2016;73(4):456-463. DOI:https://doi.org/10.1001/jamaneurol.2015.4899

42. Janakiram C., Dye B.A. A public health approach for prevention of periodontal disease // Periodontol 2000. - 2020;84(1):202-214. doi:https://doi.org/10.1111/prd.12337.

43. Kholy K.E., Genco R.J., Van Dyke T.E. Oral infections and cardio- vascular disease // Trends Endocrinol Metab. - 2015;26:315-321. DOI:https://doi.org/10.1016/j.tem.2015.03.001

44. Lamster I.B., Pagan M. Periodontal disease and the metabolic syndrome // International Dental Journal. - 2017;67:67-77. DOI:https://doi.org/10.1111/idj.12264

45. O'Neill S., O'Driscoll L. Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies // Obes Rev. - 2015;16(1):1-12. https://pubmed.ncbi.nlm.nih.gov/25407540/#affiliation-1

46. Petersen M,C,, Shulman G,I. Mechanisms of Insulin Action and Insulin Resistance // Physiol Rev. - 2018;98(4):2133-2223. doi:https://doi.org/10.1152/physrev.00063.2017.

47. Riahi S.M., Moamer S., Namdari M. et al. Patterns of clustering of the metabolic syndrome components and its association with coronary heart disease in the Multi-Ethnic Study of Atherosclerosis (MESA): A latent class analysis // Int J Cardiol. - 2018;271:13-18. https://www.sciencedirect.com/science/article/abs/pii/S0167527317370274#!

48. Salehinia F., Abdi H., Hadaegh F., Serahati S., Valizadeh M., Azizi F., Hosseinpanah F. Abdominal obesity phenotypes and incident diabetes over 12 years of follow-up: The Tehran Lipid and glucose study // Diabetes Res Clin Pract. - 2018;144:17-24. https://pubmed.ncbi.nlm.nih.gov/30036611/

49. Bragger U., Heitz-Mayfi L.J.A. ITI Treatment Guide. Biological and Hardware Complications in Implant Dentistry. Quintessence Publishing Co, Ltd. 8:214. https://www.quintessenz.de/downloads/20031_Preview_Renvert_Peri-implantitis.pdf

50. Yucel-Lindberg T., Bage T. Inflammatory mediators in the pathogenesis of periodontitis // Expert Rev Mol Med. - 2013;15:e7. DOI:https://doi.org/10.1017/erm.2013.8


Login or Create
* Forgot password?